Beyond BRCA: TP53 and Li-Fraumeni Syndrome

adrenocortical carcinomas

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Beyond BRCA: TP53 and Li-Fraumeni Syndrome

Genetic Counseling Note:  TP53 is a gene located on chromosome 17p that is often mutated, or changed, in tumors.  However, some people are born carrying one mutation in the TP53 gene in all of their cells.  These mutations are called germline mutations, and result in Li-Fraumeni Syndrome (LFS).  People with LFS have a high lifetime…

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