A 42-year-old woman underwent a breast biopsy due to an abnormal mammogram. Even though the biopsy analysis yielded benign findings, the woman’s family history with pancreatic cancer prompted the surgeon to order a 70-gene panel test to assess if she had inherited a pathogenic genetic variant that increased her cancer risk.
The results indicated the woman had a pathogenic variant in the RAD50 gene and a variant of uncertain significance (VUS) in the PALB2 gene. The surgeon recommended the woman undergo risk-reducing surgery and remove both her breasts based on the pathogenic RAD50 variant and told her not to worry about the VUS in PALB2.
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